Article
RAP1 protein activates and silences transcription of mating-type genes in yeast.
Genes & development - 1 Apr 1991
Kurtz S, Shore D
Abstract excerpt
RAP1 is a sequence-specific DNA-binding protein essential for cell growth. The occurrence of RAP1-binding sites in many promoter regions, the mating-type gene silencer elements, and telomeres suggests that RAP1 has multiple functions in the cell. To assess its role in transcription, temperature-sensitive mutations in RAP1 were generated. Analysis of rap1ts strains provides evidence that RAP1 functions in both...
Topics
- Alleles
- Crosses, Genetic
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Mating Type, Fungal
- Genotype
- Kinetics
- Mating Factor
- Peptides
- Pheromones