Article
Allelotype study of esophageal carcinoma.
Genes, chromosomes & cancer - 1 Jul 1994
Aoki T, Mori T, Du X, Nisihira T, Matsubara T, Nakamura Y
Abstract excerpt
To investigate genetic features of esophageal cancer, we have examined 93 squamous cell carcinomas of the esophagus for loss of heterozygosity (LOH), using 41 restriction fragment length polymorphism (RFLP) markers representing all autosomal chromosomes. Allelic losses at frequencies of at least 30% were observed at loci on chromosomal arms 3p (35%), 3q (30%), 5q (36%), 9p (57%), 9q (60%), 10p (33%), 13q (43%),...
Topics
- Alleles
- Autoradiography
- Blotting, Southern
- Carcinoma, Squamous Cell
- Chromosome Deletion
- Esophageal Neoplasms
- Female
- Genes, APC
- Genotype
- Heterozygote
- Humans
- Male