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Article

Hypermethylated APC DNA in Plasma and Prognosis of Patients With Esophageal Adenocarcinoma

15 Nov 2000

Abstract excerpt

BACKGROUND: The adenomatous polyposis coli (APC) locus on chromosome 5q21-22 shows frequent loss of heterozygosity (LOH) in esophageal carcinomas. However, the prevalence of truncating mutations in the APC gene in esophageal carcinomas is low. Because hypermethylation of promoter regions is known to affect several other tumor suppressor genes, we investigated whether the APC promoter region is hypermethylated in...

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PMID: 11078757
DOI: 10.1093/jnci/92.22.1805

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