Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC.

American journal of human genetics - 1 Feb 1993

Spirio L, Nelson L, Ward K, Burt R, White R, Leppert M

Abstract excerpt

Presymptomatic genetic testing for the presence of a mutant allele causing familial adenomatous polyposis coli (APC) has been difficult to perform effectively in the past because DNA markers surrounding the APC gene on chromosome 5q have not been very informative. We report results of genetic linkage studies on both research families and clinical families by using D5S346, a highly polymorphic dinucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophoresis, Polyacrylamide Gel
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Genotype

Share to Pedigree

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 8094265
PMCID: PMC1682209

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC.PMID 8094265Read ↗

Genetic characterization of the APC locus involved in familial adenomatous polyposis.Semantic proximity Read ↗

Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.Semantic proximity Read ↗

Mutation analysis of the adenomatous polyposis coli (APC) gene in Danish patients with familial adenomatous polyposis (FAP).Semantic proximity Read ↗

Screening by genomic linkage studies and mutation analysis of hereditary adenomatous polyposis coli: usefulness for clinical practice.Semantic proximity Read ↗

Improved predictive carrier testing for familial adenomatous polyposis using DNA from a single archival specimen and polymorphic markers with multiple alleles.Semantic proximity Read ↗

The use of DNA markers in the pre-clinical diagnosis of familial adenomatous polyposis.Semantic proximity Read ↗

Identification and characterization of the familial adenomatous polyposis coli gene.Semantic proximity Read ↗

Novel germline APC gene mutation in a large familial adenomatous polyposis kindred displaying variable phenotypes.Semantic proximity Read ↗

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.Semantic proximity Read ↗

Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.Semantic proximity Read ↗

Presymptomatic diagnosis of familial adenomatous polyposis coli.Semantic proximity Read ↗

Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.