Article
Ras antagonizes cAMP stimulated glucagon gene transcription in pancreatic islet cell lines.
FEBS letters - 24 Oct 1994
Gherzi R, Briata P, Fehmann H C, Göke B
Abstract excerpt
Ras, a GTP-binding protein, converts membrane tyrosine kinase signalling to changes in gene expression patterns. Utilising a rat glucagon promoter-CAT construct (p[-1.1]GLU-CAT) we demonstrate in transient transfection experiments that the oncogenic Ras inhibits cAMP-dependent activation of p[-1....
Topics
- Adenoma, Islet Cell
- Animals
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Genes, Dominant
- Genes, ras
- Glucagon
- Glucagonoma
- Insulinoma
- Mutation
- Promoter Regions, Genetic
- Protein Kinase C
- RNA, Messenger
- Rats
- Recombinant Fusion Proteins
- Signal Transduction
- Transcription, Genetic
- Transfection