Article
Ras antagonizes cAMP stimulated glucagon gene transcription in pancreatic islet cell lines.
FEBS letters - 24 Oct 1994
Gherzi R, Briata P, Fehmann H C, Göke B
Abstract excerpt
Ras, a GTP-binding protein, converts membrane tyrosine kinase signalling to changes in gene expression patterns. Utilising a rat glucagon promoter-CAT construct (p[-1.1]GLU-CAT) we demonstrate in transient transfection experiments that the oncogenic Ras inhibits cAMP-dependent activation of p[-1.1]GLU-CAT in both glucagonoma InR1-G9 and insulinoma beta-TC1 cells. Conversely, the expression of a dominant negative...
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