Article
Nuclear protein binding and functional activity of a variant insulin gene found in non-insulin-dependent diabetes mellitus.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1996
Yildiz N, Diedrich T, Knepel W
Abstract excerpt
In a subset of patients with non-insulin-dependent diabetes mellitus an 8-base pair (bp) repeat was found from -322 to -315 in the 5'-flanking region of the insulin gene. This 8-bp repeat is inserted into a sequence that is highly homologous to a sequence motif, called PISCES (pancreatic islet ce...
Topics
- Animals
- Base Sequence
- Cell Line
- Diabetes Mellitus, Type 2
- Enhancer Elements, Genetic
- Genetic Variation
- Glucagon
- Humans
- Insulin
- Islets of Langerhans
- Molecular Sequence Data
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Promoter Regions, Genetic
- Rats
- Recombinant Proteins
- Regulatory Sequences, Nucleic Acid
- Repetitive Sequences, Nucleic Acid