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Article

A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.

The Journal of biological chemistry - 25 May 1990

Knepel W, Jepeal L, Habener J F

Abstract excerpt

Interactions of nuclear proteins with cis-control elements are involved in the programmed developmental expression of the islet polypeptide hormone genes. Three transcriptional control elements within 300 base pairs of the 5'-flanking region of the rat glucagon gene interact with regulatory cellular proteins and direct transcription only in glucagon-producing islet cells. Two islet cell-specific enhancer-like...

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PMID: 2160464

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A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.PMID 2160464Read ↗

Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES).Semantic proximity Read ↗

Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans.Semantic proximity Read ↗

Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation.Semantic proximity Read ↗

Involvement of PDX-1 in activation of human insulin gene transcriptionSemantic proximity Read ↗

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The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.Semantic proximity Read ↗

Neurogenin3 Activates the Islet Differentiation Program while Repressing Its Own ExpressionSemantic proximity Read ↗

The role of the proximal CTAAT-box of the rat glucokinase upstream promoter in transcriptional control in insulin-producing cells.Semantic proximity Read ↗

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.Semantic proximity Read ↗

Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Semantic proximity Read ↗

FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start SiteSemantic proximity Read ↗

Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression.Semantic proximity Read ↗

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