A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.

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Article

A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.

The Journal of biological chemistry - 25 May 1990

Knepel W, Jepeal L, Habener J F

Abstract excerpt

Interactions of nuclear proteins with cis-control elements are involved in the programmed developmental expression of the islet polypeptide hormone genes. Three transcriptional control elements within 300 base pairs of the 5'-flanking region of the rat glucagon gene interact with regulatory cellu...

Topics

Adenoma, Islet Cell
Animals
Base Sequence
Cell Line
Cell Nucleus
DNA, Neoplasm
DNA-Binding Proteins
Deoxyribonucleases
Enhancer Elements, Genetic
Glucagon
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulinoma

Molecular Sequence Data

Mutation

Nucleotide Mapping

Oligonucleotide Probes

Pancreatic Neoplasms

Source

Open in PubMed

Identifiers

PMID: 2160464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2160464-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.PMID 2160464Read ↗

Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES).Semantic proximity Read ↗

Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans.Semantic proximity Read ↗

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Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Semantic proximity Read ↗

FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start SiteSemantic proximity Read ↗

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