Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.

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Article

Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.

The Journal of biological chemistry - 5 Feb 1992

Kalvakolanu D V, Liu J, Hanson R W, Harter M L, Sen G C

Abstract excerpt

Adenovirus infection of hepatoma cells inhibited transcription of the phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) gene and virtually eliminated transcription of a chimeric gene which contained the PEPCK promoter linked to the structural gene for chloramphenicol acetyltransferase (CAT). This effect is due to the viral protein E1A, since adenovirus containing a deletion in the E1A gene did not...

Topics

Adenoviridae
Adenovirus Early Proteins
CCAAT-Enhancer-Binding Proteins
Carcinoma, Hepatocellular
Chloramphenicol O-Acetyltransferase
Cyclic AMP
Cyclic AMP Response Element-Binding Protein
DNA-Binding Proteins
Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Viral

Mutation

Nuclear Proteins

Oncogene Proteins, Viral

Phosphoenolpyruvate Carboxykinase (GTP)

Promoter Regions, Genetic

Protein Kinases

Proto-Oncogene Proteins c-jun

TATA Box

Source

Open in PubMed

Identifiers

PMID: 1310318

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1310318-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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