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Article

Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.

The Journal of biological chemistry - 5 Feb 1992

Kalvakolanu D V, Liu J, Hanson R W, Harter M L, Sen G C

Abstract excerpt

Adenovirus infection of hepatoma cells inhibited transcription of the phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) gene and virtually eliminated transcription of a chimeric gene which contained the PEPCK promoter linked to the structural gene for chloramphenicol acetyltransferase (CAT). This effect is due to the viral protein E1A, since adenovirus containing a deletion in the E1A gene did not...

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Share to Carcinoma, Hepatocellular
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 1310318

Genes

CAT
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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