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Article

Changes in activation gating of IsK potassium currents brought about by mutations in the transmembrane sequence.

FEBS letters - 24 Oct 1994

Wilson G G, Sivaprasadarao A, Findlay J B, Wray D

Abstract excerpt

Expression of the rat kidney IsK protein in Xenopus oocytes produces slowly-activating potassium channel currents. We have investigated the relationship between structure and function of the single putative membrane-spanning domain using site-directed mutagenesis. Six mutants were constructed in which consecutive individual amino acids (53 to 58) of the transmembrane region were substituted by cysteine....

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Identifiers

PMID: 7957868
DOI: 10.1016/0014-5793(94)01058-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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