Article
A mutation in the pore of the sodium channel alters gating.
Biophysical journal - 1 May 1995
Tomaselli G F, Chiamvimonvat N, Nuss H B, Balser J R, Pérez-García M T, Xu R H, Orias D W, Backx P H, Marban E
Abstract excerpt
Ion permeation and channel gating are classically considered independent processes, but site-specific mutagenesis studies in K channels suggest that residues in or near the ion-selective pore of the channel can influence activation and inactivation. We describe a mutation in the pore of the skeletal muscle Na channel that alters gating. This mutation, I-W53C (residue 402 in the mu 1 sequence), decreases the...
Topics
- Amino Acid Sequence
- Animals
- Cadmium
- Cell Membrane
- Chorionic Gonadotropin
- Electrophysiology
- Female
- Ion Channel Gating
- Kinetics
- Mammals
- Models, Structural