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Article

A mutation in the pore of the sodium channel alters gating.

Biophysical journal - 1 May 1995

Tomaselli G F, Chiamvimonvat N, Nuss H B, Balser J R, Pérez-García M T, Xu R H, Orias D W, Backx P H, Marban E

Abstract excerpt

Ion permeation and channel gating are classically considered independent processes, but site-specific mutagenesis studies in K channels suggest that residues in or near the ion-selective pore of the channel can influence activation and inactivation. We describe a mutation in the pore of the skeletal muscle Na channel that alters gating. This mutation, I-W53C (residue 402 in the mu 1 sequence), decreases the...

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Identifiers

PMID: 7612823
DOI: 10.1016/S0006-3495(95)80358-9
PMCID: PMC1282084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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