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Article

P2X(1) receptor subunit contribution to gating revealed by a dominant negative PKC mutant.

Biochemical and biophysical research communications - 1 Mar 2002

Ennion Steven J, Evans Richard J

Abstract excerpt

The family of ATP-gated P2X receptor channels have a conserved protein kinase C site in the N-terminal intracellular domain. This site was disrupted in human P2X(1) receptors by the mutation T18A. T18A mutants were expressed at normal levels in Xenopus oocytes; however, the peak current amplitude was reduced by >99% and showed approximately 10 fold faster desensitisation in response to ATP than wild type (WT)...

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Identifiers

PMID: 11855833
DOI: 10.1006/bbrc.2002.6488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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