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Article

Asymmetric organization of the pore region of the epithelial sodium channel.

The Journal of biological chemistry - 18 Apr 2003

Li Jinqing, Sheng Shaohu, Perry Clint J, Kleyman Thomas R

Abstract excerpt

Epithelial sodium channels (ENaCs) are composed of three homologous subunits that have regions preceding the second transmembrane domain (also referred as pre-M2) that form part of the channel pore. To identify residues within this region of the beta-subunit that line the pore, we systematically mutated residues Gln(523)-Ile(536) to cysteine. Wild type and mutant mouse ENaCs were expressed in Xenopus oocytes, and...

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Identifiers

PMID: 12576470
DOI: 10.1074/jbc.M300149200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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