Article
The protein IsK is a dual activator of K+ and Cl- channels.
Nature - 28 Oct 1993
Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J
Abstract excerpt
The protein IsK (M(r) 14,500) is present in epithelial cells, heart, uterus and lymphocytes and induces slowly activating K+ currents when expressed in Xenopus oocytes. The finding that mutations of its single transmembrane segment altered channel gating or selectivity has suggested that IsK is a channel-forming protein. But IsK does not exhibit the K+ channel hallmarks (a conserved K+ selective pore (H5) flanked...
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