Article
The protein IsK is a dual activator of K+ and Cl- channels.
Nature - 28 Oct 1993
Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J
Abstract excerpt
The protein IsK (M(r) 14,500) is present in epithelial cells, heart, uterus and lymphocytes and induces slowly activating K+ currents when expressed in Xenopus oocytes. The finding that mutations of its single transmembrane segment altered channel gating or selectivity has suggested that IsK is a...
Topics
- Amino Acid Sequence
- Animals
- Chloride Channels
- Cloning, Molecular
- Dogs
- Humans
- Membrane Potentials
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Oocytes
- Phosphoproteins
- Potassium Channels
- Potassium Channels, Voltage-Gated
- Xenopus