Article
Ion currents through mutant phospholemman channel molecules.
Receptors & channels - 1 Jan 1999
Chen Z H, Jones L R, Moorman J R
Abstract excerpt
Phospholemman (PLM), a small membrane protein with a single transmembrane domain, is a major substrate for protein kinases in muscle. In lipid bilayers, PLM forms ion channels with two unusual features--selectivity for the zwitterion taurine, and switching among cation- and anion-selective conformations. To investigate the molecular determinants of channel behavior, we measured ion currents through (1) PLM...
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