Article
Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene.
Carcinogenesis - 1 Jul 1996
Wessner L L, Fan M, Schaeffer D O, McEntee M F, Miller M S
Abstract excerpt
A pharmacogenetic mouse model was utilized to determine the role of Cyp1a1 expression on the formation of Ki-ras mutations in lung tumors following transplacental exposure to polycyclic aromatic hydrocarbons (PAHs). A backcross between Ah responsive male B6D2F1 mice and nonresponsive female DBA m...
Topics
- Animals
- Base Sequence
- Body Weight
- Carcinogens
- Crosses, Genetic
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 Enzyme System
- DNA Primers
- Female
- Genes, ras
- Lung Neoplasms
- Male
- Methylcholanthrene
- Mice
- Mice, Inbred DBA
- Mice, Inbred Strains
- Molecular Sequence Data
- Oxidoreductases