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Article

Temporal changes in K-ras mutant fraction in lung tissue of big blue B6C3F₁ mice exposed to ethylene oxide.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2013

Parsons Barbara L, Manjanatha Mugimane G, Myers Meagan B, McKim Karen L, Shelton Sharon D, Wang Yiying, Gollapudi B Bhaskar, Moore Nigel P, Haber Lynne T, Moore Martha M

Abstract excerpt

Ethylene oxide (EO) is a genotoxicant and a mouse lung carcinogen, but whether EO is carcinogenic through a mutagenic mode of action remains unclear. To investigate this question, 8-week-old male Big Blue B6C3F₁ mice (10 mice/group) were exposed to EO by inhalation-6 h/day, 5 days/week for 4 weeks (0, 10, 50, 100, or 200 ppm EO) and 8 or 12 weeks (0, 100, or 200 ppm EO). Lung DNA samples were analyzed for levels...

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PMID: 24029818
DOI: 10.1093/toxsci/kft190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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