Article
Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours.
Carcinogenesis - 1 Jun 1994
Stanley L A, Blackburn D R, Devereaux S, Foley J, Lord P G, Maronpot R R, Orton T C, Anderson M W
Abstract excerpt
The majority of genotoxic carcinogen-induced liver tumours of the sensitive B6C3F1 mouse contain activated H-ras oncogenes. Such mutations also occur in hepatocarcinogenesis-resistant strains. In order to determine whether this is true of non-genotoxic carcinogen-induced tumours, liver tumours in...
Topics
- Alleles
- Animals
- Clofenapate
- Codon
- DNA Damage
- Genes, ras
- Liver Neoplasms, Experimental
- Mice
- Mice, Inbred C57BL
- Mice, Nude
- Mutation