Article
Temporal changes in the mutant frequency and mutation spectra of the 61st codon of the H-ras oncogene following exposure of B6C3F1 mice to N-nitrosodiethylamine (DEN).
Carcinogenesis - 1 Jul 1992
Richardson K K, Rexroat M A, Helvering L M, Copple D M, Richardson F C
Abstract excerpt
Hepatocellular tumors were induced in 15 day old male B6C3F1 mice following a single exposure to N-nitrosodiethylamine (DEN; 5 mg/kg, i.p.). Tumors were collected at 38 and 65 weeks to compare the frequencies and types of mutations in the 61st codon of the H-ras oncogene. The 61st codon was ampli...
Topics
- Alleles
- Animals
- Base Sequence
- Codon
- DNA
- Diethylnitrosamine
- Genes, ras
- Liver
- Liver Neoplasms
- Male
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Time Factors