Activation of cellular oncogenes by chemical carcinogens in Syrian hamster embryo fibroblasts.

doi:10.1289/ehp.9088175

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Article

Activation of cellular oncogenes by chemical carcinogens in Syrian hamster embryo fibroblasts.

Environmental health perspectives - 1 Aug 1990

Ebert R, Barrett J C, Wiseman R W, Pechan R, Reiss E, Röllich G, Schiffmann D

Abstract excerpt

Carcinogen-induced point mutations resulting in activation of ras oncogenes have been demonstrated in various experimental systems such as skin carcinogenesis, mammary, and liver carcinogenesis. In many cases, the data support the conclusion that these point mutations are critical changes in the...

Topics

Animals
Carcinogens
Cell Transformation, Neoplastic
Cricetinae
DNA
Embryo, Mammalian
Fibroblasts
Gene Expression Regulation
Mesocricetus
Methylation
Mutation
Proto-Oncogenes

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