Article
DNA replication arrest and tolerance to DNA methylation damage.
Carcinogenesis - 1 Oct 1994
Zhukovskaya N, Branch P, Aquilina G, Karran P
Abstract excerpt
Inhibition of DNA replication by different DNA damaging agents has been investigated in HeLaMR cells and a methylation damage-tolerant variant HeLa5A1. In synchronous HeLaMR and HeLa5A1 cells exposed to N-ethyl-N-nitrosourea or ionizing radiation in mid-G1 phase, DNA synthesis was inhibited in th...
Topics
- DNA Damage
- DNA Replication
- DNA, Neoplasm
- Ethylnitrosourea
- HeLa Cells
- Humans
- Methylation
- Methylnitrosourea
- Phenotype
- Signal Transduction