Properties of mer- HeLa cells sensitive or resistant to the cytotoxic effects of MNU; effects on DNA synthesis and of post treatment with caffeine.

doi:10.1016/0027-5107(90)90168-4

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Article

Properties of mer- HeLa cells sensitive or resistant to the cytotoxic effects of MNU; effects on DNA synthesis and of post treatment with caffeine.

Mutation research - 1 Jan 2000

Roberts J J, Basham C

Abstract excerpt

A line of HeLa cells was shown to be particularly sensitive to N-methyl-N-nitrosurea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), but not to a variety of other cytotoxic agents. A resistant line (designated HeLa/A22), was derived by treating HeLa cells repeatedly with MNU. Both the sens...

Topics

Caffeine
Cell Survival
Chromosomes, Human
DNA
Drug Resistance
HeLa Cells
Humans
Karyotyping
Methylnitronitrosoguanidine
Methylnitrosourea
Phenotype

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