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Article

Properties of mer- HeLa cells sensitive or resistant to the cytotoxic effects of MNU; effects on DNA synthesis and of post treatment with caffeine.

Mutation research - 1 Jan 2000

Roberts J J, Basham C

Abstract excerpt

A line of HeLa cells was shown to be particularly sensitive to N-methyl-N-nitrosurea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), but not to a variety of other cytotoxic agents. A resistant line (designated HeLa/A22), was derived by treating HeLa cells repeatedly with MNU. Both the sensitive (HeLa) and resistant (HeLa/A22) cells have a mer- phenotype based both on their reduced rates of loss of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 2233807
DOI: 10.1016/0027-5107(90)90168-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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