Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools.

doi:10.1074/jbc.M303952200

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools.

The Journal of biological chemistry - 2 Jan 2004

Koç Ahmet, Wheeler Linda J, Mathews Christopher K, Merrill Gary F

Abstract excerpt

The relationship between dNTP levels and DNA synthesis was investigated using alpha factor-synchronized yeast treated with the ribonucleotide reductase inhibitor hydroxyurea (HU). Although HU blocked DNA synthesis and prevented the dNTP pool expansion that normally occurs at G1/S, it did not exhaust the levels of any of the four dNTPs, which dropped to about 80% of G1 levels. When dbf4 yeast that are ts for...

Topics

DNA Replication
DNA, Fungal
Deoxyribonucleotides
G1 Phase
Genotype
Hydroxyurea
Kinetics
S Phase
Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 14573610
DOI: 10.1074/jbc.M303952200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics