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Genetic and biochemical characterization of the CHO-UV-1 mutant defective in postreplication recovery of DNA.

Cancer research - 15 Apr 1990

Hentosh P, Collins A R, Correll L, Fornace A J, Giaccia A, Waldren C A

Abstract excerpt

The CHO-UV-1 mutant, a Chinese hamster ovary cell with defective postreplication recovery of DNA, is 2- to 4-fold more sensitive than its wild-type counterpart (CHO-77256) to the lethal effects of ethylating agents and UV radiation; it is also hypersensitive (10- to 20-fold) to some DNA-methylating and -cross-linking agents. We studied the CHO-UV-1 mutant further to define its phenotype in terms of DNA damage...

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PMID: 2317821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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