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Article

Genetic and biochemical characterization of the CHO-UV-1 mutant defective in postreplication recovery of DNA.

Cancer research - 15 Apr 1990

Hentosh P, Collins A R, Correll L, Fornace A J, Giaccia A, Waldren C A

Abstract excerpt

The CHO-UV-1 mutant, a Chinese hamster ovary cell with defective postreplication recovery of DNA, is 2- to 4-fold more sensitive than its wild-type counterpart (CHO-77256) to the lethal effects of ethylating agents and UV radiation; it is also hypersensitive (10- to 20-fold) to some DNA-methylati...

Topics

Animals
Caffeine
Cell Line
Cell Survival
Cricetinae
Cricetulus
DNA
DNA Damage
DNA Replication
Ethyl Methanesulfonate
Female
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Methylnitrosourea

Mutation

Ovary

Ultraviolet Rays

Source

Identifiers

PMID: 2317821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2317821-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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