A microplate version of the DNA-synthesis inhibition test for rapid detection of DNA-alteration potentials.

doi:10.1016/0003-2697(90)90462-i

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Article

A microplate version of the DNA-synthesis inhibition test for rapid detection of DNA-alteration potentials.

Analytical biochemistry - 1 Jun 1990

Heil J, Reifferscheid G, Pischtschan E, Klös M, Jungblut H D, Zahn R K

Abstract excerpt

A microplate version of the DNA-synthesis inhibition test (DIT) for fast detection of DNA-alteration potentials has been developed. The DIT is based on the concept that DNA damage causes inhibition of DNA synthesis that becomes detectable some time after replicating cells have been in contact wit...

Topics

Autoanalysis
Benzo(a)pyrene
DNA
DNA Damage
DNA Replication
HeLa Cells
Humans
Mutagenicity Tests
Mutagens
Mutation
Nitroquinolines

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