Article
Dde I restriction fragment length polymorphism of the alpha 2-adrenoceptor gene does not correlate with blood pressure in the F2 generation obtained from crossing stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.
Journal of hypertension - 1 Mar 1994
Kobayashi S, Umemura S, Hirawa N, Iwamoto T, Yamaguchi S, Tamura K, Takasaki I, Ishii M
Abstract excerpt
OBJECTIVE: A pathogenetic role of altered alpha 2-adrenoceptors in essential hypertension has been suggested, based on studies in humans and animals. To examine the role of the alpha 2-adrenoceptor in genetically hypertensive rats, we compared the alpha 2-adrenoceptor genes of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats by restriction fragment length polymorphism analysis...
Topics
- Alleles
- Animals
- Blood Pressure
- Cerebrovascular Disorders
- Crosses, Genetic
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Female
- Hypertension
- Male