Article
Cosegregation of blood pressure with a kallikrein gene family polymorphism.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 1991
Pravenec M, Kren V, Kunes J, Scicli A G, Carretero O A, Simonet L, Kurtz T W
Abstract excerpt
It has recently been proposed that sequence variation in the gene coding for tissue kallikrein might be involved in the pathogenesis of hypertension. However, molecular evidence of an association between a sequence alteration in the kallikrein gene family and the transmission of increased blood pressure has never been reported. In 32 recombinant inbred (RI) strains derived from the spontaneously hypertensive rat...
Topics
- Animals
- Blood Pressure
- Blotting, Southern
- DNA
- DNA Fingerprinting
- DNA Probes
- Genes
- Genotype
- Kallikreins
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length