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Article

Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure.

The Journal of clinical investigation - 1 Apr 1990

Kurtz T W, Simonet L, Kabra P M, Wolfe S, Chan L, Hjelle B L

Abstract excerpt

The spontaneously hypertensive rat (SHR) exhibits alterations in the renin-angiotensin-aldosterone system which are similar to those that characterize patients with "nonmodulating" hypertension, a common and highly heritable form of essential hypertension. Accordingly, we determined whether the inheritance of a DNA restriction fragment length polymorphism (RFLP) marking the renin gene of the SHR was associated...

Topics

Alleles
Amino Acid Sequence
Animals
Blood Pressure
Female
Hypertension
Male
Polymorphism, Restriction Fragment Length
Rats
Rats, Inbred Lew
Rats, Inbred SHR

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Renin

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Open in PubMed Open full text

Identifiers

PMID: 1969424
DOI: 10.1172/JCI114572
PMCID: PMC296571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1969424-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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