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Article

The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure.

Neuron - 1 Oct 1994

Lahey T, Gorczyca M, Jia X X, Budnik V

Abstract excerpt

The Drosophila tumor suppressor gene lethal (1) discs large (dlg) encodes a protein necessary for normal cell growth in epithelial and brain tissue. It shares high sequence identity to the mammalian synaptic proteins PSD-95 and SAP-70, whose functions are unknown. To determine the localization and role of dlg at synapses, we investigated its distribution and the effects of dlg mutations on Drosophila...

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Identifiers

PMID: 7946331
DOI: 10.1016/0896-6273(94)90249-6
PMCID: PMC4661177

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure.PMID 7946331Read ↗

The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse.Semantic proximity Read ↗

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Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.Semantic proximity Read ↗

Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila.Semantic proximity Read ↗

DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function.Semantic proximity Read ↗

Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation.Semantic proximity Read ↗

A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.Semantic proximity Read ↗

Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large.Semantic proximity Read ↗

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