Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation.

Cell - 6 Aug 1999

Koh Y H, Popova E, Thomas U, Griffith L C, Budnik V

Abstract excerpt

Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mutant synapses and dramatically increased extrajunctional DLG. Decreased CaMKII activity caused...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
Share to Calcium-Calmodulin-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Insect Proteins

Share to Luminescent Proteins

Share to Neuromuscular Junction

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 10458610
DOI: 10.1016/s0092-8674(00)81964-9
PMCID: PMC4656018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation.PMID 10458610Read ↗

Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila.Semantic proximity Read ↗

Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.Semantic proximity Read ↗

The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse.Semantic proximity Read ↗

The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure.Semantic proximity Read ↗

Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors.Semantic proximity Read ↗

A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.Semantic proximity Read ↗

Mechanisms underlying the role of DISC1 in synaptic plasticitySemantic proximity Read ↗

Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.Semantic proximity Read ↗

Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.Semantic proximity Read ↗

Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.Semantic proximity Read ↗

Cell-type specific visualization and biochemical isolation of endogenous synaptic proteins in miceSemantic proximity Read ↗

Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.