Article
Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.
Neuron - 10 Jun 2010
Banovic Daniel, Khorramshahi Omid, Owald David, Wichmann Carolin, Riedt Tamara, Fouquet Wernher, Tian Rui, Sigrist Stephan J, Aberle Hermann
Abstract excerpt
Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) that cause a severe reduction in bouton numbers at neuromuscular junctions (NMJs). In accord with...
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