Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila.

doi:10.1186/1741-7007-3-1

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Article

Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila.

BMC biology - 8 Jan 2005

Chen Kaiyun, Featherstone David E

Abstract excerpt

BACKGROUND: Drosophila discs-large (DLG) is the sole representative of a large class of mammalian MAGUKs, including human DLG, SAP 97, SAP102, and PSD-95. MAGUKs are thought to be critical for postsynaptic assembly at glutamatergic synapses. However, glutamate receptor cluster formation has never been examined in Drosophila DLG mutants. The fly neuromuscular junction (NMJ) is a genetically-malleable model...

Topics

Animals
Drosophila
Drosophila Proteins
Excitatory Postsynaptic Potentials
Genes, Tumor Suppressor
Mutation
Presynaptic Terminals
Receptors, AMPA
Tumor Suppressor Proteins

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PMID: 15638945
DOI: 10.1186/1741-7007-3-1
PMCID: PMC545058

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