Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome.

doi:10.1176/appi.ajp.2010.10040484

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Article

Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome.

The American journal of psychiatry - 1 Dec 2010

Feyder Michael, Karlsson Rose-Marie, Mathur Poonam, Lyman Matthew, Bock Roland, Momenan Reza, Munasinghe Jeeva, Scattoni Maria Luisa, Ihne Jessica, Camp Marguerite, Graybeal Carolyn, Strathdee Douglas, Begg Alison, Alvarez Veronica A, Kirsch Peter, Rietschel Marcella, Cichon Sven, Walter Henrik, Meyer-Lindenberg Andreas, Grant Seth G N, Holmes Andrew

Abstract excerpt

OBJECTIVE: Research is increasingly linking autism spectrum disorders and other neurodevelopmental disorders to synaptic abnormalities ("synaptopathies"). PSD-95 (postsynaptic density-95, DLG4) orchestrates protein-protein interactions at excitatory synapses and is a major functional bridge interconnecting a neurexinneuroligin-SHANK pathway implicated in autism spectrum disorders. METHOD: The authors...

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Identifiers

PMID: 20952458
DOI: 10.1176/appi.ajp.2010.10040484
PMCID: PMC3146008

Genes

DLG4
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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