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Article

Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene.

Molecular and cellular biology - 1 Mar 2001

Caruana G, Bernstein A

Abstract excerpt

The discs large (Dlg) protein, or synapse-associated protein 97 (SAP97), is a member of the membrane-associated guanylate kinase family of multidomain scaffolding proteins which recruits transmembrane and signaling molecules to localized plasma membrane sites. Murine dlg is the homologue of the Drosophila dlg tumor suppressor gene. The loss of dlg function in Drosophila disrupts cellular growth control,...

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Identifiers

PMID: 11238884
DOI: 10.1128/MCB.21.5.1475-1483.2001
PMCID: PMC86693

Genes

PSD

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene.PMID 11238884Read ↗

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Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila.Semantic proximity Read ↗

Discs-Large and Strabismus are functionally linked to plasma membrane formation.Semantic proximity Read ↗

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Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia.Semantic proximity Read ↗

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DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance.Semantic proximity Read ↗

Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.Semantic proximity Read ↗

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