Article
Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Feb 1997
Kohn Y, Ebstein R P, Heresco-Levy U, Shapira B, Nemanov L, Gritsenko I, Avnon M, Lerer B
Abstract excerpt
The dopamine D4 receptor (DRD4) is a candidate gene in the search for a genetic etiology of schizophrenia and for pharmacogenetic factors in the response to antipsychotic treatment. Previous work has not found linkage or association of a polymorphism in exon 3 of this gene with diagnosis of schiz...
Topics
- Antipsychotic Agents
- Clozapine
- Ethnicity
- Exons
- Gene Frequency
- Genotype
- Humans
- Israel
- Jews
- Polymorphism, Genetic
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Schizophrenia