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Article

Gene–gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia

17 Nov 2017

Abstract excerpt

Clozapine is the drug of choice for treatment-resistant schizophrenia. However, its use is associated with variable clinical responses and serious adverse effects. Polymorphisms in genes encoding proteins involved in synaptic neurotransmission may account for such variability. Here, we studied independent and epistatic genetic associations of polymorphisms in DRD4 (120-bp duplication) and COMT (Val158Met) with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29087970
DOI: 10.1097/fpc.0000000000000314

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