Article
Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine.
The International journal of neuroscience - 1 Nov 2005
Zhao Ai-Ling, Zhao Jing-Ping, Zhang Yu-Hu, Xue Zhi-Min, Chen Jin-Dong, Chen Xiao-Gang
Abstract excerpt
To investigate the relationship between 48 bp variant number tandem repeat polymorphism in dopamine D4 receptor gene and response to clozapine in schizophrenic patients, the authors included 81 inpatients with a DSM-IV diagnosis of schizophrenia and patients meeting criteria for refractory to treatment were excluded. This study found that the frequencies of five 48 bp repeats homozygous genotype and five 48 bp...
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