Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration.

Progress in neuro-psychopharmacology & biological psychiatry - 27 Apr 2012

Hwang Rudi, Tiwari Arun K, Zai Clement C, Felsky Daniel, Remington Eli, Wallace Tessa, Tong Ryan P, Souza Renan P, Oh Gabriel, Potkin Steven G, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L

Abstract excerpt

OBJECTIVES: This study aimed to: 1) replicate previously reported associations between dopamine D4 receptor gene (DRD4) polymorphisms and antipsychotic (AP) response in a clozapine (CLZ) response sample; and 2) explore possible associations of polymorphisms across dopamine D5 receptor gene (DRD5) as well as other DRD4 regions. METHODS: DRD4 exon III 48-bp, intron I (G)(n), and 120-bp repeat polymorphisms, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Black People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clozapine

Share to Genetic Variation

Share to Receptors, Dopamine D4

Share to Schizophrenia

Share to Treatment Outcome

Share to White People

Source

Identifiers

PMID: 22203087
DOI: 10.1016/j.pnpbp.2011.11.018

Genes

DRD4
DRD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration.PMID 22203087Read ↗

Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response.Semantic proximity Read ↗

Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine.Semantic proximity Read ↗

Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response.Semantic proximity Read ↗

Dopamine D4 receptor gene (DRD4) variants and schizophrenia: meta-analyses.Semantic proximity Read ↗

Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients.Semantic proximity Read ↗

Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations.Semantic proximity Read ↗

Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia: an updateSemantic proximity Read ↗

Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment.Semantic proximity Read ↗

Gene–gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophreniaSemantic proximity Read ↗

Polymorphisms in Schizophrenia-Related Genes Are Potential Predictors of Antipsychotic Treatment Resistance and Refractoriness.Semantic proximity Read ↗

Pharmacogenetics of Antipsychotic Drug Treatment: Update and Clinical ImplicationsSemantic proximity Read ↗

Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.