Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

14 Aug 2017

Abstract excerpt

Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond. Herein we report analyses of 160 BRCA1 and BRCA2 germline mutation-associated breast and ovarian tumors. Retention of the normal BRCA1 or BRCA2 allele (absence of locus-specific loss of heterozygosity (LOH)) is observed in 7% of BRCA1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28831036
DOI: 10.1038/s41467-017-00388-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriersPMID 28831036Read ↗

Prevalence of homologous recombination biomarkers in multiple tumor types: an observational study.Semantic proximity Read ↗

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancerSemantic proximity Read ↗

Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer.Semantic proximity Read ↗

Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes.Semantic proximity Read ↗

Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883).Semantic proximity Read ↗

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis.Semantic proximity Read ↗

BRCA1 mutations in primary breast and ovarian carcinomas.Semantic proximity Read ↗

Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays.Semantic proximity Read ↗

Molecular profiles of BRCA1-associated ovarian cancer treated by platinum-based therapy: Analysis of primary, residual and relapsed tumors.Semantic proximity Read ↗

Loss of heterozygosity: what is it good for?Semantic proximity Read ↗

Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.Semantic proximity Read ↗

Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.