Article
Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers.
International journal of cancer - 1 Aug 2000
Russell P A, Pharoah P D, De Foy K, Ramus S J, Symmonds I, Wilson A, Scott I, Ponder B A, Gayther S A
Abstract excerpt
Germline mutations in the BRCA1 gene cause inherited susceptibility to breast and ovarian cancers. However, somatic mutations of BRCA1 are rare in sporadic breast and ovarian tumours. To establish whether BRCA1 is altered during the development of sporadic ovarian cancer by mechanisms other than somatic mutation, we have analysed 57 sporadic epithelial ovarian tumours for BRCA1 protein and RNA expression. Reduced...
Topics
- BRCA1 Protein
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Gene Deletion
- Genes, BRCA1
- Heteroduplex Analysis
- Humans
- Loss of Heterozygosity
- Mutation
- Neoplasm Proteins
- Ovarian Neoplasms
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger