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Article

Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers.

International journal of cancer - 1 Aug 2000

Russell P A, Pharoah P D, De Foy K, Ramus S J, Symmonds I, Wilson A, Scott I, Ponder B A, Gayther S A

Abstract excerpt

Germline mutations in the BRCA1 gene cause inherited susceptibility to breast and ovarian cancers. However, somatic mutations of BRCA1 are rare in sporadic breast and ovarian tumours. To establish whether BRCA1 is altered during the development of sporadic ovarian cancer by mechanisms other than somatic mutation, we have analysed 57 sporadic epithelial ovarian tumours for BRCA1 protein and RNA expression. Reduced...

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Share to BRCA1 Protein
Share to DNA, Neoplasm
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heteroduplex Analysis

Share to Loss of Heterozygosity

Share to Ovarian Neoplasms

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 10897034
DOI: 10.1002/1097-0215(20000801)87:3<317::aid-ijc2>3.0.co;2-b

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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