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Article

BRCA2 mutations in primary breast and ovarian cancers.

Nature genetics - 1 Jun 1996

Lancaster J M, Wooster R, Mangion J, Phelan C M, Cochran C, Gumbs C, Seal S, Barfoot R, Collins N, Bignell G, Patel S, Hamoudi R, Larsson C, Wiseman R W, Berchuck A, Iglehart J D, Marks J R, Ashworth A, Stratton M R, Futreal P A

Abstract excerpt

The second hereditary breast cancer gene, BRCA2, was recently isolated. Germline mutations of this gene predispose carriers to breast cancer, and, to a lesser extent, ovarian cancer. Loss of heterozygosity (LOH) at the BRCA2 locus has been observed in 30-40% of sporadic breast and ovarian tumours...

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Mutation
Molecular Sequence Data
Base Sequence
Aged
DNA Primers
Genetic Markers

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Identifiers

PMID: 8640235
DOI: 10.1038/ng0696-238

Genes

BRCA2
BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8640235-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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BRCA2 mutations in primary breast and ovarian cancers.PMID 8640235Read ↗

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Low incidence of BRCA2 mutations in breast carcinoma and other cancers.Semantic proximity Read ↗

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Mutation analysis in the BRCA2 gene in primary breast cancers.Semantic proximity Read ↗

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