Article
Frequency of germline and somatic BRCA1 mutations in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1998
Berchuck A, Heron K A, Carney M E, Lancaster J M, Fraser E G, Vinson V L, Deffenbaugh A M, Miron A, Marks J R, Futreal P A, Frank T S
Abstract excerpt
Germline mutations in the BRCA1 tumor suppressor gene are thought to be the most common cause of hereditary ovarian cancer. The aim of this study was to explore further the role of BRCA1 alterations in the development of ovarian cancers. We sought to determine whether somatic BRCA1 mutations are...
Topics
- Adult
- Aged
- Female
- Genes, BRCA1
- Germ-Line Mutation
- Humans
- Loss of Heterozygosity
- Middle Aged
- Mutation
- Ovarian Neoplasms