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Article

High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and molecular associations.

Cancer genetics - 1 Mar 2012

Rzepecka Iwona K, Szafron Lukasz, Stys Agnieszka, Bujko Mateusz, Plisiecka-Halasa Joanna, Madry Radoslaw, Osuch Beata, Markowska Janina, Bidzinski Mariusz, Kupryjanczyk Jolanta

Abstract excerpt

BRCA1 dysfunction may occur by different mechanisms that are rarely evaluated concomitantly. We aimed to analyze BRCA1 germline mutations, loss of heterozygosity (LOH) and promoter methylation in unselected ovarian carcinomas in the context of their clinicopathologic characteristics and other molecular changes. BRCA1 mutations were analyzed in 257 carcinomas using single-strand conformation polymorphism (SSCP),...

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Identifiers

PMID: 22469508
DOI: 10.1016/j.cancergen.2011.12.005

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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