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Article

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

11 Oct 1994

Abstract excerpt

Restriction of dietary calories reduces cancer formation in experimental animals and probably also in humans. This effect is generally attributed to the inhibitory effect of fasting on cell proliferation. Here we studied the effect of fasting on physiological cell death through apoptosis by using rat liver as a model. (i) In normal liver, involution of hyperplasia by apoptosis was reinforced by food withdrawal...

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Identifiers

PMID: 7937932
DOI: 10.1073/pnas.91.21.9995

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