Article
Compensatory apoptosis in preneoplastic liver of a transgenic mouse model for viral hepatocarcinogenesis.
Cancer letters - 25 Dec 1998
Koike K, Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Tsutsumi T, Kimura S
Abstract excerpt
The HBx protein of hepatitis B virus has been shown to induce hepatocellular carcinoma in transgenic mice as direct evidence for its involvement in hepatocarcinogenesis. In these transgenic mice, however, it is not clear why hepatocytes do not acquire a neoplastic phenotype by 13 months old despite the continuous growth stimulation by the HBx protein from 2 months old. In this study, we show that the accelerated...
Topics
- Aging
- Animals
- Apoptosis
- Disease Models, Animal
- Hepatitis B Antigens
- Hepatitis B virus
- In Situ Nick-End Labeling
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Transgenic
- Phenotype
- Precancerous Conditions
- Trans-Activators
- Viral Regulatory and Accessory Proteins