Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643.

doi:10.1093/carcin/15.1.111

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Article

Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643.

Carcinogenesis - 1 Jan 1994

Marsman D S, Popp J A

Abstract excerpt

The biological potential of hepatic foci and tumors induced by peroxisome proliferators such as Wy-14,643 has been poorly characterized. In this study, male F-344 rats (n = 20/group/time point) were fed Wy-14,643 (0.1%) for 22, 37 or 52 weeks ('W-22', 'W-37' or 'W-52' respectively). At each time...

Topics

Adenoma, Liver Cell
Adenosine Triphosphatases
Animals
Carcinogens
Cell Division
Liver
Liver Neoplasms, Experimental
Male
Microbodies
Organ Size
Phenotype
Precancerous Conditions
Pyrimidines
Rats
Rats, Inbred F344
Staining and Labeling

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