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Article

Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma.

The Journal of urology - 1 Apr 1994

Brewster S F, Browne S, Brown K W

Abstract excerpt

We present a restriction fragment length polymorphism (RFLP) analysis of 29 benign and 30 malignant prostatic tumors, using polymorphic DNA probes to the putative tumor suppressor genes DCC (Deleted in Colorectal Carcinoma; chromosome 18q21.3), nm23-H1 (17q21.3), APC (Adenomatous Polyposis Coli; 5q21) and p53 (17p13). Six of 23 evaluable cancers (26%) showed loss of heterozygosity (LOH) at DCC; 5 were advanced...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7510345
DOI: 10.1016/s0022-5347(17)35186-8

Genes

DCC
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma.PMID 7510345Read ↗

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas.Semantic proximity Read ↗

Allelic loss on chromosomes 8p, 22q and 18q (DCC) in human prostate cancer.Semantic proximity Read ↗

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.Semantic proximity Read ↗

Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.Semantic proximity Read ↗

Frequent loss of expression and loss of heterozygosity of the putative tumor suppressor gene DCC in prostatic carcinomas.Semantic proximity Read ↗

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.Semantic proximity Read ↗

Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q.Semantic proximity Read ↗

The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder.Semantic proximity Read ↗

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.Semantic proximity Read ↗

Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.Semantic proximity Read ↗

Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression.Semantic proximity Read ↗

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