The DCC gene suppresses the malignant phenotype of transformed human epithelial cells.

Article

The DCC gene suppresses the malignant phenotype of transformed human epithelial cells.

Oncogene - 20 Apr 1995

Klingelhutz A J, Hedrick L, Cho K R, McDougall J K

Abstract excerpt

Loss of heterozygosity and loss of expression of the deleted in colon cancer (DCC) gene is frequently observed in a number of different cancer types. To determine if the DCC gene plays a direct role in tumor suppression, wild-type full-length or truncated DCC cDNA constructs were transfected into...

Topics

Animals
Cell Adhesion
Cell Transformation, Neoplastic
Cells, Cultured
DNA, Complementary
Genes, DCC
Humans
Male
Mice
Phenotype
Transfection

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