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Article

The DCC gene suppresses the malignant phenotype of transformed human epithelial cells.

Oncogene - 20 Apr 1995

Klingelhutz A J, Hedrick L, Cho K R, McDougall J K

Abstract excerpt

Loss of heterozygosity and loss of expression of the deleted in colon cancer (DCC) gene is frequently observed in a number of different cancer types. To determine if the DCC gene plays a direct role in tumor suppression, wild-type full-length or truncated DCC cDNA constructs were transfected into nitrosomethylurea (NMU) transformed tumorigenic HPV-immortalized human epithelial cells that had allelic loss and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7731713

Genes

DCC
NMU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The DCC gene suppresses the malignant phenotype of transformed human epithelial cells.PMID 7731713Read ↗

Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression.Semantic proximity Read ↗

Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene.Semantic proximity Read ↗

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.Semantic proximity Read ↗

Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer.Semantic proximity Read ↗

Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas.Semantic proximity Read ↗

Mutation and expression of the DCC gene in human lung cancer.Semantic proximity Read ↗

Frequent loss of expression and loss of heterozygosity of the putative tumor suppressor gene DCC in prostatic carcinomas.Semantic proximity Read ↗

The DCC gene: structural analysis and mutations in colorectal carcinomas.Semantic proximity Read ↗

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.Semantic proximity Read ↗

Role of the Dependence Receptor DCC in Colorectal Cancer PathogenesisSemantic proximity Read ↗

Identification of a chromosome 18q gene that is altered in colorectal cancers.Semantic proximity Read ↗

DCC expression is altered by multiple mechanisms in brain tumours.Semantic proximity Read ↗

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