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Article

Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.

Journal of virology - 1 Nov 1994

Freund R, Bauer P H, Crissman H A, Bradbury E M, Benjamin T L

Abstract excerpt

We have examined the growth properties of polyomavirus large T-antigen mutants that are unable to bind pRB, the product of the retinoblastoma tumor suppressor gene. These mutants grow poorly on primary mouse cells yet grow well on NIH 3T3 and other established mouse cell lines. Preinfection of primary baby mouse kidney (BMK) epithelial cells with wild-type simian virus 40 renders these cells permissive to growth...

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PMID: 7933105
DOI: 10.1128/JVI.68.11.7227-7234.1994
PMCID: PMC237162

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