Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.

doi:10.1128/JVI.68.11.7227-7234.1994

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Article

Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.

Journal of virology - 1 Nov 1994

Freund R, Bauer P H, Crissman H A, Bradbury E M, Benjamin T L

Abstract excerpt

We have examined the growth properties of polyomavirus large T-antigen mutants that are unable to bind pRB, the product of the retinoblastoma tumor suppressor gene. These mutants grow poorly on primary mouse cells yet grow well on NIH 3T3 and other established mouse cell lines. Preinfection of pr...

Topics

3T3 Cells
Animals
Antigens, Polyomavirus Transforming
Capsid
Capsid Proteins
Cell Cycle
Cells, Cultured
DNA, Viral
Mice
Mutation
Polyomavirus
Retinoblastoma Protein
Transcription, Genetic

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