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Article

Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.

Molecular and cellular biology - 1 Dec 1998

Mullane K P, Ratnofsky M, Culleré X, Schaffhausen B

Abstract excerpt

Polyomavirus causes a broad spectrum of tumors as the result of the action of its early proteins. This work compares signaling from middle T antigen (MT), the major transforming protein, to that from small T antigen (ST). The abilities of MT mutants to promote cell cycle progression in serum-starved NIH 3T3 cells were compared. Transformation-defective mutants lacking association with SHC or with...

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Identifiers

PMID: 9819441
DOI: 10.1128/MCB.18.12.7556
PMCID: PMC109336

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