Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice.

doi:10.1016/0042-6822(92)90247-m

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Article

Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice.

Virology - 1 Dec 1992

Freund R, Sotnikov A, Bronson R T, Benjamin T L

Abstract excerpt

A mutant strain of polyoma virus encoding a truncated middle T protein has been studied for its ability to replicate and induce tumors following inoculation into newborn mice. Virus replication in the acute period prior to expected onset of tumors as well as persistence of virus in older animals...

Topics

Aging
Animals
Animals, Newborn
Antigens, Polyomavirus Transforming
Kidney
Mice
Mice, Inbred C3H
Mutation
Neoplasms, Experimental
Polyomavirus
Tumor Virus Infections
Virus Replication

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